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Last Updated: September 29, 2020

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Patent: 6,071,517

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Summary for Patent: 6,071,517
Title: Bispecific heteroantibodies with dual effector functions
Abstract:Bispecific molecules which react both with the high-affinity Fc.gamma. receptor of human effector cells and with a target cell surface antigen are disclosed. Binding of the molecules to the Fc receptors found on effector cells is not blocked by human immunoglobulin G. The molecules are useful for targeting human effector cells (e.g. macrophages) against cells bearing the target antigen. For this purpose, bispecific molecules can be constructed containing the binding region derived from an anti-Fc.gamma. receptor antibody and the binding region derived from an antibody specific for the target antigen. Targeted effector cells can be used to destroy cells bearing the target cell surface antigen by cell-mediated antibody dependent cytolysis and by complement-fixation.
Inventor(s): Fanger; Michael W. (Lebanon, NH), Guyre; Paul M. (Hanover, NH), Ball; Edward D. (Norwich, VT)
Assignee: Medarex, Inc. (NJ)
Application Number:08/359,931
Patent Claims:see list of patent claims

Details for Patent 6,071,517

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Csl Behring Ag CARIMUNE human immunoglobulin g INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 102367 1 2009-02-10   Start Trial Medarex, Inc. (NJ) 2017-06-06 search
Csl Behring Ag PRIVIGEN human immunoglobulin g LIQUID 125201 1 2009-01-20   Start Trial Medarex, Inc. (NJ) 2017-06-06 search
Bio Products Laboratory Limited GAMMAPLEX human immunoglobulin g SOLUTION 125329 1 2017-04-07   Start Trial Medarex, Inc. (NJ) 2017-06-06 search
Csl Behring Ag HIZENTRA human immunoglobulin g LIQUID 125350 1 2020-01-01   Start Trial Medarex, Inc. (NJ) 2017-06-06 search
Adma Biologics, Inc. ASCENIV human immunoglobulin g LIQUID 125590 1 2019-04-01   Start Trial Medarex, Inc. (NJ) 2017-06-06 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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