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Last Updated: July 11, 2020

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Patent: 6,068,976

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Summary for Patent: 6,068,976
Title: Modulators of ob gene and screening methods therefor
Abstract:This invention relates to the isolation and cloning of the promoter and other control regions of a human ob gene. It provides a method for identifying and screening for agents useful for the treatment of diseases and pathological conditions affected by the level of expression of an ob gene. These agents interact directly or indirectly with the promoter or other control regions of the ob gene. A PPAR.gamma. agonist, BRL49653, has been identified to be useful in treating anorexia, cachexia, and other diseases characterized by insufficient food intake or body weight loss. Modulators of ob gene expression may be used to treat other diseases such as obesity, diabetes, hypertension, cardiovascular diseases and infertility.
Inventor(s): Briggs; Michael R. (Downingtown, PA), Auwerx; Johan (Millionfosse, FR), de Vos; Piet (Zingem, BE), Staels; Bart (Kraainem, BE), Croston; Glenn E. (San Diego, CA), Miller; Stephen G. (San Diego, CA)
Assignee: Ligand Pharmaceuticals Incorporated (San Diego, CA)
Application Number:08/618,100
Patent Claims:see list of patent claims

Details for Patent 6,068,976

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Start Trial Ligand Pharmaceuticals Incorporated (San Diego, CA) 2015-03-20 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Start Trial Ligand Pharmaceuticals Incorporated (San Diego, CA) 2015-03-20 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Start Trial Ligand Pharmaceuticals Incorporated (San Diego, CA) 2015-03-20 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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