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Generated: July 17, 2019

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Patent: 6,028,118

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Summary for Patent: 6,028,118
Title: Methods of using extracts of shark cartilage
Abstract:The present invention relates to cartilage extracts and to a method of producing the same. Shark cartilage extracts having anti-angiogenic, anti-tumoral, anti-inflammatory and anti-collagenolytic activities have been obtained by an improved process. The process comprises the steps of obtaining a homogenate of cartilage in an aqueous solution, this homogenate being separated in a solid fraction (SOLID EXTRACT) and a liquid fraction which was further fractionated to obtain a LIQUID EXTRACT having molecules of a molecular weight comprised between 0 to 500 kDa. The composition of the liquid extract has then been investigated by different ways. Further fractionation of this extract led to the preliminary characterization of some of its active components. Due to the multiplicity of biological activities of the total liquid extract, it can be used for treating numerous diseases or conditions such as those having components selected from the group consisting of tumor proliferation, angiogenesis, inflammation and collagenolysis. Several cosmetic applications based on the capacity of the liquid extract to improve skin barrier function are also under the scope of this invention. These extracts have no offensive effect on normal body functions. Therefore, these shark cartilage extracts have a very promising therapeutic value. The process for the obtention of cartilage extracts is simple and efficient. The unexpectedly valuable products obtained by this process are therefore an indication of a new and non-obvious process.
Inventor(s): Dupont; Eric (St. Nicholas, CA), Brazeau; Paul (Montreal, CA), Juneau; Christina (Ste. Foy, CA), Maes; Daniel H. (Huntington, NY), Marenus; Kenneth (Dix Hills, NY)
Assignee: Les Laboratoires Aeterna Inc. (Quebec, CA)
Application Number:08/693,535
Patent Claims:see list of patent claims

Details for Patent 6,028,118

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source
Advance Biofactures SANTYL collagenase VIAL 101995 001 1965-06-04 ➤ Sign Up Les Laboratoires Aeterna Inc. (Quebec, CA) ➤ Sign Up RX search
Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source

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International Patent Family for US Patent 6,028,118

Country Patent Number Publication Date
South Africa 9606726 Feb 18, 1997
World Intellectual Property Organization (WIPO) 9532722 Dec 07, 1995
World Intellectual Property Organization (WIPO) 9623512 Aug 08, 1996
World Intellectual Property Organization (WIPO) 9716197 May 09, 1997
United States of America 2003013858 Jan 16, 2003
United States of America 2004081703 Apr 29, 2004
United States of America 5618925 Apr 08, 1997
Country Patent Number Publication Date

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Serving hundreds of leading biopharmaceutical companies globally:

Healthtrust
McKesson
Covington
Daiichi Sankyo
Argus Health
US Army

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