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Last Updated: December 5, 2021

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Patent: 6,004,748

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Summary for Patent: 6,004,748
Title: Method of inhibiting transcription utilizing nuclear receptors
Abstract:This invention provides a method of inhibiting the transcription of a gene, which is activated by AP-1 or an AP-1 component, comprising binding AP-1 or the component with a nuclear receptor so as to prevent the binding of AP-1 to the gene. The nuclear receptor can be the retinoic acid receptor, glucocorticoid receptor, vitamin D3 receptor, thyroid receptor, or estrogen receptor. Also provided is a composition of matter comprising AP-1 or an AP-1 component bound to a nuclear receptor. These methods and compositions can be used to treat arthritis and cancer.
Inventor(s): Pfahl; Magnus (Solana Beach, CA), Karin; Michael (San Diego, CA)
Assignee: La Jolla Cancer Research Foundation (La Jolla, CA)
Application Number:08/757,349
Patent Claims:see list of patent claims

Details for Patent 6,004,748

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Smith & Nephew, Inc. SANTYL collagenase Ointment 101995 1965-06-04 ⤷  Try it Free 2010-10-10
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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Serving leading biopharmaceutical companies globally:

Johnson and Johnson
Boehringer Ingelheim
Harvard Business School

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