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Last Updated: October 1, 2020

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Patent: 6,001,630

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Summary for Patent: 6,001,630
Title: Pharmaceutical compositions of chondroitinase ABC isolated from Proteus vulgaris ATCC 6896
Abstract:A crystallizable, purified chondroitinase ABC having a molecular weight of about 100,000 dalton by the measurement of the SDS-polyacrylamide gel electrophoresis (SDS-PAGE) and the measurement by the gel permeation chromatography method, having alanine as the N-terminal amino acid and proline as the C-terminal amino acid is disclosed. A process for the purification of the crystallizable purified chondroitinase ABC comprising removing nucleic acid from an surfactant solution extract obtained from cells of chondroitinase ABC-producing microorganisms and chromatographically treating by concentration gradient elution using a weak cation exchange resin or a strong cation exchange resin is disclosed. A composition comprising a chondroitinase and serum albumin, gelatin, or a nonionic surfactant is used to treat disc displacement. The enzyme is isolate from Proteus vulgaris ATCC 6896.
Inventor(s): Ichikawa; Shinichi (Kamifukuoka, JP), Torikai; Misako (Wako, JP), Miyachi; Isao (Tokorozawa, JP)
Assignee: Seikagaku Kogyo Kabushiki Kaisha (Seikagaku Corporation) (Tokyo, JP)
Application Number:08/444,309
Patent Claims:see list of patent claims

Details for Patent 6,001,630

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck Sharp & Dohme Corp. ZOSTAVAX zoster vaccine live INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION 125123 1 2006-05-25   Start Trial Seikagaku Kogyo Kabushiki Kaisha (Seikagaku Corporation) (Tokyo, JP) 2016-12-14 search
Merck Sharp & Dohme Corp. ZOSTAVAX zoster vaccine live INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION 125123 001 2006-05-25   Start Trial Seikagaku Kogyo Kabushiki Kaisha (Seikagaku Corporation) (Tokyo, JP) 2016-12-14 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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