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Last Updated: November 29, 2021

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Patent: 5,998,209

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Summary for Patent: 5,998,209
Title: Generation of large genomic DNA deletions
Abstract:The method of the invention provides the use of a replacement-type targeting construct to delete large fragments of genomic DNA by gene targeting. The replacement targeting construct, which may contain a selectable marker, is constructed to contain two regions of sequences which are homologous to the 5\' and 3\' flanking sequences of the targeted locus. After transfection of the targeting construct into the desired cell line, gene targeted-mediated deletions are identified by selection and further characterized. The invention is useful in any situation where one would want to create a large genomic deletion. Examples of suitable loci include MHC Class I and II antigens and immunoglobulin genes, including, for example, variable and constant region of kappa, lambda, or heavy chains.
Inventor(s): Jokobovits; Aya (Menlo Park, CA), Tsuda; Hirohisa (Kanagawa, JP)
Assignee: Abgenix, Inc. (Fremont, CA)
Application Number:08/808,139
Patent Claims:see list of patent claims

Details for Patent 5,998,209

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 1986-06-04 ⤷  Try it Free 2015-04-21
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 ⤷  Try it Free 2015-04-21
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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