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Last Updated: September 24, 2020

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Patent: 5,989,888

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Summary for Patent: 5,989,888
Title: Purified mixture of collagenase I, collagenase II and two other proteases
Abstract:A purified enzyme mixture useful for isolating cells or cell clusters from tissue is disclosed. The mixture includes at least two collagenase enzymes, at least two other proteases, and additional non-protease components. The mixture is purified by removing at least some of the non-protease components. The purified mixture may then be used to isolate cells or cell clusters from tissue. Also disclosed are the essential components of the purified enzyme mixture as well as preferred ranges and ratios of these essential components for isolating cells or cell clusters from tissue. Finally, a dissociation system is disclosed that can be used with the purified enzyme mixture to dissociate tissue and recover cells or cell clusters.
Inventor(s): Dwulet; Francis E. (Greenwood, IN), Ellis; Bernice B. (Greenfield, IN), Gill; John F. (Indianapolis, IN), Jacobsen; Linda B. (Indianapolis, IN), Smith; Marilyn E. (McCordsville, IN), Waters; David G. (Indianapolis, IN)
Assignee: Roche Diagnostics Corporation (Indianapolis, IN)
Application Number:09/042,295
Patent Claims:see list of patent claims

Details for Patent 5,989,888

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial Roche Diagnostics Corporation (Indianapolis, IN) 2016-01-24 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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