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Last Updated: August 11, 2020

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Patent: 5,942,390

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Summary for Patent: 5,942,390
Title: Method of diagnosing predisposition for ulcerative colitis in Jewish population by detection of interleukin-1 receptor antagonist polymorphism
Abstract:A novel, differential association between allele 2 of the variable number of tandem repeats polymorphism at intron 2 of the human IL-1 receptor antagonist gene and ulcerative colitis in humans of Jewish ancestry has been discovered. In accordance with the present invention, there is provided methods of screening for ulcerative colitis in human subjects of Jewish ancestry comprising detecting the presence or absence of nucleic acid of the subject encoding allele 2 of the variable number of tandem repeats polymorphism at intron 2 of the human IL-1 receptor antagonist gene, wherein the presence of nucleic acid encoding allele 2 is indicative of ulcerative colitis. Kits useful for screening for ulcerative colitis in human subjects of Jewish ancestry are also provided.
Inventor(s): Cominelli; Fabio (Charlottesville, VA), Pizarro; Theresa (Charlottesville, VA), Rotter; Jerome I. (Los Angeles, CA), Yang; Huiying (Cerritos, CA)
Assignee: Cedars-Sinai Medical Center (Los Angeles, CA)
Application Number:08/587,911
Patent Claims:see list of patent claims

Details for Patent 5,942,390

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Start Trial Cedars-Sinai Medical Center (Los Angeles, CA) 2039-02-26 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Start Trial Cedars-Sinai Medical Center (Los Angeles, CA) 2039-02-26 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Start Trial Cedars-Sinai Medical Center (Los Angeles, CA) 2039-02-26 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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