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Last Updated: July 11, 2020

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Patent: 5,935,823

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Summary for Patent: 5,935,823
Title: Totally synthetic affinity reagents
Abstract:A novel process for producing novel and/or improved heterofunctional binding fusion proteins termed Totally Synthetic Affinity Reagents (TSARS) is disclosed. TSARs are concatenated heterofunctional polypeptides or proteins comprising at least two functional regions: a binding domain with affinity for a ligand and a second effector peptide portion that is chemically or biologically active. In one embodiment, the heterofunctional polypeptides or proteins further comprise a linker peptide portion between the binding domain and the second active peptide portion. The linker peptide can be either susceptible or not susceptible to cleavage by enzymatic or chemical means. Novel and/or improved heterofunctional binding reagents as well as methods for using the reagents for a variety of in vitro and in vivo applications are also disclosed.
Inventor(s): Fowlkes; Dana M. (Chapel Hill, NC), Kay; Brian K. (Chapel Hill, NC)
Assignee: The University of North Carolina at Chapel Hill (Chapel Hill, NC)
Application Number:08/420,945
Patent Claims:see list of patent claims

Details for Patent 5,935,823

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial The University of North Carolina at Chapel Hill (Chapel Hill, NC) 2016-08-10 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

International Patent Family for US Patent 5,935,823

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Serving leading biopharmaceutical companies globally:

Harvard Business School
Baxter
Medtronic
Johnson and Johnson
McKinsey
Merck

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