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Generated: September 19, 2019

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Patent: 5,905,185

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Summary for Patent: 5,905,185
Title: Protein C production in non-human transgenic mammals
Abstract:Methods for producing protein C in transgenic non-human mammals are disclosed. The protein C is modified at the two-chain cleavage site between the light and heavy chains of protein C from Lys-Arg to R.sub.1 -R.sub.2 -R.sub.3 -R.sub.4 where R.sub.1 through R.sub.4 are individually Arg or Lys. DNA segments encoding modified protein C are introduced into the germ line of a non-human mammals, and the mammal or its female progeny produces milk containing protein C expressed from the introduced DNA segments. The protein C expressed from the introduced DNA segments has anticoagulant activity when activated. Non-human mammalian embryos and transgenic non-human mammals carrying DNA segments encoding heterologous protein C are also disclosed.
Inventor(s): Garner; Ian (Edinburgh, GB), Cottingham; Ian R. (Edinburgh, GB), Temperley; Simon M. (Edinburgh, GB), Foster; Donald C. (Seattle, WA), Sprecher; Cindy A. (Seattle, WA), Prunkard; Donna E. (Seattle, WA)
Assignee: PPL Therapeutics (Edinburgh, GB) ZymoGenetics, Inc. (Seattle, WA)
Application Number:08/756,506
Patent Claims:see list of patent claims

Details for Patent 5,905,185

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04 ➤ Sign Up PPL Therapeutics (Edinburgh, GB) ZymoGenetics, Inc. (Seattle, WA) 2015-11-30 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04 ➤ Sign Up PPL Therapeutics (Edinburgh, GB) ZymoGenetics, Inc. (Seattle, WA) 2015-11-30 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04 ➤ Sign Up PPL Therapeutics (Edinburgh, GB) ZymoGenetics, Inc. (Seattle, WA) 2015-11-30 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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