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Last Updated: November 27, 2021

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Patent: 5,876,988

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Summary for Patent: 5,876,988
Title: Selection marker gene free recombinant strains: method for obtaining them and the use of these strains
Abstract:The present invention discloses a selection marker free system which can be used to introduce genetic modifications in bacteria, yeasts and fungi. The system can be employed to introduce or delete desired genes or DNA fragments in the genome of the indicated host species without leaving any undesired DNA i.e. the selection marker used for selection of transformants or other DNA used for cloning. In this way strains have been developed containing only desired genes introduced at desired chromosomal sites. Similarly, desired DNA fragments have been deleted or replaced at desired sites.
Inventor(s): Selten; Gerardus Cornelius Maria (Berkel en Rodenrijs, NL), Swinkels; Bart Willem (Delft, NL), Van Gorcom; Robertus Franciscus Maria (Delft, NL)
Assignee: Gist-brocades BV (Ma Delft, NL)
Application Number:08/880,557
Patent Claims:see list of patent claims

Details for Patent 5,876,988

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 1986-06-04 ⤷  Try it Free 2013-07-23
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 ⤷  Try it Free 2013-07-23
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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Serving leading biopharmaceutical companies globally:

Medtronic
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Colorcon

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