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Last Updated: October 1, 2020

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Patent: 5,876,988

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Summary for Patent: 5,876,988
Title: Selection marker gene free recombinant strains: method for obtaining them and the use of these strains
Abstract:The present invention discloses a selection marker free system which can be used to introduce genetic modifications in bacteria, yeasts and fungi. The system can be employed to introduce or delete desired genes or DNA fragments in the genome of the indicated host species without leaving any undesired DNA i.e. the selection marker used for selection of transformants or other DNA used for cloning. In this way strains have been developed containing only desired genes introduced at desired chromosomal sites. Similarly, desired DNA fragments have been deleted or replaced at desired sites.
Inventor(s): Selten; Gerardus Cornelius Maria (Berkel en Rodenrijs, NL), Swinkels; Bart Willem (Delft, NL), Van Gorcom; Robertus Franciscus Maria (Delft, NL)
Assignee: Gist-brocades BV (Ma Delft, NL)
Application Number:08/880,557
Patent Claims:see list of patent claims

Details for Patent 5,876,988

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Start Trial Gist-brocades BV (Ma Delft, NL) 2013-07-23 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Start Trial Gist-brocades BV (Ma Delft, NL) 2013-07-23 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Start Trial Gist-brocades BV (Ma Delft, NL) 2013-07-23 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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