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Last Updated: September 23, 2020

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Patent: 5,861,299

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Summary for Patent: 5,861,299
Title: Genetic construct of which protein coding DNA comprises introns and is designed for protein production in transgenic animals
Abstract:Proteinaceous products can be produced by transgenic animals having genetic constructs integrated into their genome. The construct comprises a 5\'-flanking sequence from a mammalian milk protein gene (such as beta-lactoglobulin) and DNA coding for a heterologous protein other than the milk protein (for example a serin protease such as alpha.sub.1 -antitrypsin or a blood factor such as Factor VIII or IX). The protein-coding DNA comprises at least one, but not all, of the introns naturally occurring in a gene coding for the heterologous protein. The 5\'-flanking sequence is sufficient to drive expression of the heterologous protein.
Inventor(s): Archibald; Alan Langskill (Edinburgh, GB), Clark; Anthony John (Midlothian, GB), Harris; Stephen (Edinburgh, GB), McClenaghan; Margaret (Edinburgh, GB), Simons; Jonathan Paul (Edinburgh, GB), Whitelaw; Christopher Bruce Alexander (Edinburgh, GB)
Assignee: PPL Therapeutics (Scotland) Limited (Edinburgh, GB6)
Application Number:08/343,884
Patent Claims:see list of patent claims

Details for Patent 5,861,299

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Start Trial PPL Therapeutics (Scotland) Limited (Edinburgh, GB6) 2008-11-11 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Start Trial PPL Therapeutics (Scotland) Limited (Edinburgh, GB6) 2008-11-11 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Start Trial PPL Therapeutics (Scotland) Limited (Edinburgh, GB6) 2008-11-11 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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