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Last Updated: September 24, 2020

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Patent: 5,856,138

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Summary for Patent: 5,856,138
Title: Human parathyroid hormone muteins and production thereof
Abstract:Disclosed are (1) a human parathyroid hormone mutein which comprises at least one modification selected from the group consisting of (i) deletion of 3 to 6 amino acid residues on the N-terminal side in the amino acid sequence of human parathyroid hormones, (ii) substitution of another lipophilic amino acid residue for at least one methionine residue in the amino acid sequence, and (iii) substitution of a cysteine residue for one amino acid residue within the region of amino acid residue Nos. 34 to 47 in the amino acid sequence; (2) a recombinant DNA having a nucleotide sequence coding for the human parathyroid hormone mutein described in (1); (3) a vector containing the recombinant DNA described in (2); (4) a vector in which the recombinant DNA described in (2) is inserted into a region controlled by an E. coli T7 promoter; (5) a transformant which is transformed by the recombinant DNA described in (2); and a process for producing a human parathyroid hormone mutein which comprises cultivating the transformant described in (5) in a culture medium.
Inventor(s): Fukuda; Tsunehiko (Kyoto, JP)
Assignee: Takeda Chemical Industries, Ltd. (Osaka, JP)
Application Number:08/733,446
Patent Claims:see list of patent claims

Details for Patent 5,856,138

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 001 2015-01-23   Start Trial Takeda Chemical Industries, Ltd. (Osaka, JP) 2011-08-07 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23   Start Trial Takeda Chemical Industries, Ltd. (Osaka, JP) 2011-08-07 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 003 2015-01-23   Start Trial Takeda Chemical Industries, Ltd. (Osaka, JP) 2011-08-07 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 004 2015-01-23   Start Trial Takeda Chemical Industries, Ltd. (Osaka, JP) 2011-08-07 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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