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Last Updated: September 18, 2020

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Patent: 5,837,260

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Summary for Patent: 5,837,260
Title: Chimeric hepatitis A vaccine
Abstract:A full-length cDNA copy of an attenuated, cell culture-adapted hepatitis-A virus genome has been constructed. The HAV cDNA when inserted, without the oligo (dG) oligo (dC) tails, into an RNA transcription vector yielded a plasmid designated pHAV/7. Transfection of monkey kidney cells with pHAV/7 DNA yielded HAV. Transfection with RNA transcripts produced in vitro from pHAV/7 yielded about 10-fold more HAV than transfection with pHAV/7 DNA. HAV thus produced are useful as a vaccine.
Inventor(s): Cohen; Jeffrey I. (Brighton, MA), Purcell; Robert H. (Boyds, MD), Feinstone; Stephen M. (Washington, DC), Ticehurst; John R. (Bethesda, MD)
Assignee: The United of America as represented by the Department of Health and Human Services (Washington, DC)
Application Number:08/473,304
Patent Claims:see list of patent claims

Details for Patent 5,837,260

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Glaxosmithkline Biologicals Sa HAVRIX hepatitis a vaccine INJECTION, SUSPENSION 103475 1 2007-04-13   Start Trial The United of America as represented by the Department of Health and Human Services (Washington, DC) 2015-11-17 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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Serving leading biopharmaceutical companies globally:

Boehringer Ingelheim
Harvard Business School
Express Scripts

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