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Generated: September 19, 2019

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Patent: 5,834,212

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Summary for Patent: 5,834,212
Title: Anti-human stromelysin monoclonal antibody and method for diagnosis of rheumatoid arthritis by enzyme immunoassay
Abstract:Anti-human stromelysin monoclonal antibodies reactive with latent and active forms of stromelysin without discrimination between the two, each being immunoreactive with only one of the antigenic determinants of human stromelysin, are provided. The use of a combination of two such monoclonal antibodies which specifically react with different antigenic determinants of human stromelysin renders it possible to accurately determine the amount of human stromelysin in human body fluids, and thus to carry out the diagnosis of rheumatoid arthritis. There are thus provided said monoclonal antibodies per se, a sandwich enzyme immunoassay for the determination of the amount of human stromelysin in human body fluid samples using a combination of two such monoclonal antibodies, and a method for the diagnosis of rheumatoid arthritis using said immunoassay.
Inventor(s): Okada; Yasunori (Matto-shi, Ishikawa-ken, 924, JP), Shinmei; Masayoshi (Tokorozawa-shi, Saitama-ken, 359, JP), Hayakawa; Taro (Tenpaku-ku, Nagoya-shi, Aichi-ken, 468, JP), Iwata; Kazushi (Takaoka-shi, Toyama-ken, 933, JP), Korin; Yumi (Kahoku-gun, Ishikawa-ken, 929-12, JP), Kodama; Shuji (Takaoka-shi, Toyama-ken, 933, JP), Yoshida; Shinichi (Toyama-shi, Toyama-ken, 930, JP)
Assignee:
Application Number:08/417,847
Patent Claims:see list of patent claims

Details for Patent 5,834,212

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Advance Biofactures SANTYL collagenase VIAL 101995 001 1965-06-04 ➤ Sign Up 2015-11-10 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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