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Last Updated: September 30, 2020

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Patent: 5,824,870

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Summary for Patent: 5,824,870
Title: Commercial production of aprotinin in plants
Abstract:A method for commercial production of aprotinin entails heterologous expression of the protein in plants, preferably at a level such that aprotinin accounts for at least 0.1% of the total extracted protein. An aprotinin-expressing plant also has potential of increased insecticidal resistance by virtue of producing the protein. A genetic map of the integration locus allows identification of plants derived from the transgenic plant. This approach also reveals genetic loci on a plant chromosome that support high levels of gene expression and can be used as site of integration for expression of other genes of interest.
Inventor(s): Baszczynski; Chris (Urbandale, IA), Czapla; Thomas (Urbandale, IA), Hood; Elizabeth (Clive, IA), Meyer; Terry EuClaire (Urbandale, IA), Peterson; David (Johnston, IA), Rao; A. Gururaj (Urbandale, IA), Register, III; James C. (Ames, IA), Witcher; Derrick (Urbandale, IA), Howard; John A. (West Des Moines, IA)
Application Number:08/554,161
Patent Claims:see list of patent claims

Details for Patent 5,824,870

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Bayer Hlthcare TRASYLOL aprotinin INJECTABLE;INJECTION 020304 001 1994-02-07   Start Trial 2039-02-26 DISCN search
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Start Trial 2039-02-26 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Start Trial 2039-02-26 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Start Trial 2039-02-26 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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