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Last Updated: November 28, 2021

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Patent: 5,821,057

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Summary for Patent: 5,821,057
Title: Assay for agents that affect cholesterol 7alpha-hydroxylase expression and a characterization of its regulatory elements
Abstract:DNA regulatory elements that control cholesterol 7.alpha.-hydroxylase (CYP7) expression are disclosed, including a CYP7 minigene that comprises nucleotides downstream from about -371 of the proximal promoter region through about the middle of intron II, inclusive of intron I. This minigene further is stably transfected into a cell line, along with a reporter gene. A method is provided for screening agents that inhibit or stimulate expression of the minigene.
Inventor(s): Chiang; John Y. L. (Stow, OH), Stroup; Diane (Alliance, OH)
Assignee: Northeastern Ohio Universities (Rootstown, OH)
Application Number:08/562,985
Patent Claims:see list of patent claims

Details for Patent 5,821,057

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 1986-06-04 ⤷  Free Forever Trial 2039-02-26
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 ⤷  Free Forever Trial 2039-02-26
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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