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Last Updated: September 28, 2020

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Patent: 5,820,862

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Summary for Patent: 5,820,862
Title: T cell epitopes of the major allergens from dermatophagoides (house dust mite)
Abstract:The present invention provides isolated peptides of the major protein allergens of the genus Dermatophagoides. Peptides within the scope of the invention comprises at least one T cell epitope, or preferably at least two T cell epitopes of a protein allergen selected from the allergens Der p I, Der p II, Der f I, or Der f II. The invention also pertains to modified peptides having similar or enhanced therapeutic properties as the corresponding, naturally-occurring allergen or portion thereof, but having reduced side effects. The invention further provides nucleic acid sequences coding for peptides of the invention. Methods of treatment or of diagnosis of sensitivity to house dust mites in an individual and therapeutic compositions comprising one or more peptides of the invention are also provided.
Inventor(s): Garman; Richard D. (Arlington, MA), Greenstein; Julia L. (West Newton, MA), Kuo; Mei-chang (Winchester, MA), Rogers; Bruce L. (Belmont, MA), Franzen; Henry M. (Watertown, MA), Chen; Xian (North Chelmsford, MA), Evans; Sean (Acton, MA), Shaked; Ze\'ev (Berkeley, CA)
Assignee: Immulogic Pharmaceutical Corporation (Waltham, MA)
Application Number:08/482,142
Patent Claims:see list of patent claims

Details for Patent 5,820,862

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck Sharp & Dohme Corp. ZOSTAVAX zoster vaccine live INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION 125123 001 2006-05-25   Start Trial Immulogic Pharmaceutical Corporation (Waltham, MA) 2015-10-13 search
Merck Sharp & Dohme Corp. ZOSTAVAX zoster vaccine live INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION 125123 1 2006-05-25   Start Trial Immulogic Pharmaceutical Corporation (Waltham, MA) 2015-10-13 search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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