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Generated: July 16, 2019

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Patent: 5,817,911

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Summary for Patent: 5,817,911
Title: Transgenic mice expressing alveolar MCP-1
Abstract:A transgenic, non-human animal is provided which overexpresses a gene responsible for the accumulation of monocytes and leukocytes. The animal is preferably a mammal and more preferably a mouse, rat or guinea pig. The transgenic animal is created by artificially inserting a transgene into a fertilized egg of the animal which egg is then inserted within a pseudo pregnant female where it is allowed to grow. The transgene preferably expresses human Monocyte Chemoattractant Protein-1 (MCP-1) and more preferably overexpresses MCP-1 in type II pulmonary epithelial cells. The invention includes DNA constructs and vectors containing the constructs with a particularly preferred vector being SPC-MCP-1. The plasmid SPC-MCP-1 includes a promoter operatively linked to a human MCP-1 coding sequence. The transgenic animal provides a useful animal model for testing drugs for their efficacy with respect to the treatment of diseases and conditions which result in an acceptable high accumulation of monocytes and/or lymphocytes.
Inventor(s): Williams; Lewis T. (Tiburon, CA), Gunn; Michael Dee (San Francisco, CA)
Assignee: Regents of the University of California (Alameda, CA)
Application Number:08/420,001
Patent Claims:see list of patent claims

Details for Patent 5,817,911

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04 ➤ Try a Free Trial Regents of the University of California (Alameda, CA) ➤ Try a Free Trial RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04 ➤ Try a Free Trial Regents of the University of California (Alameda, CA) ➤ Try a Free Trial RX search
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04 ➤ Try a Free Trial Regents of the University of California (Alameda, CA) ➤ Try a Free Trial RX search
Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source

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Mallinckrodt
Colorcon
Boehringer Ingelheim
Fuji
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Covington

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