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Last Updated: September 29, 2020

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Patent: 5,814,716

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Summary for Patent: 5,814,716
Title: Cell lines from a transgenic mouse which express biologically active IX factor
Abstract:Cell lines have been prepared from transgenic mice comprised of a first exogenous DNA sequence encoding human factor IX which is controlled by a promoter region specific for hepatic cells and a second exogenous DNA sequence encoding an oncogene, such as the SV40 virus gene encoding the T-antigen or the mouse c-myc gene, which is controlled by a promoter region specific for hepatic cells. Promoter regions specific for hepatic cells included the promoter region for the factor IX gene and the promoter region for the .alpha.-1 antitrypsin gene. The cultured cells produce biologically active human factor IX which is then isolated from the culture media.
Inventor(s): Jallat; Sophie (Strasbourg, FR), Meulien; Pierre (Paris, FR), Pavirani; Andrea (Strasbourg, FR), Perraud; Frederic (Strasbourg, FR)
Assignee: Transgene S.A. (Courbevoie, FR)
Application Number:08/394,210
Patent Claims:see list of patent claims

Details for Patent 5,814,716

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Start Trial Transgene S.A. (Courbevoie, FR) 2015-09-29 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Start Trial Transgene S.A. (Courbevoie, FR) 2015-09-29 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Start Trial Transgene S.A. (Courbevoie, FR) 2015-09-29 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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