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Last Updated: December 8, 2019

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Patent: 5,814,460

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Summary for Patent: 5,814,460
Title: Method for generating and screening useful peptides
Abstract:The invention allows the generation and screening of a large population of peptides for the presence of peptides which bind a particular macromolecule or macromolecular complex with high affinity, and further allows the favored net synthesis of analyzable quantities of such peptides, by using is the \"trap\" a macromolecule or macromolecular complex for which binding of the peptide is desired. The starting mixture is preferably spiked with a peptide having some affinity for the target macromolecule so that mutation of the spike or \"lead\" peptide is favored. The development of improved binding peptides through scrambling may be dynamically monitored by initially binding the target with an insolubilized ligand, and then looking for an increase in the concentration of the target in the soluble phase as a result of the displacement of the reference ligand by scrambled peptides.
Inventor(s): Venton; Duane L. (Lombard, IL), Hopfinger; Anton J. (Lake Forest, IL), Lebreton; Guy (Oak Park, IL)
Assignee: Diatide, Inc. (Londonderry, NH)
Application Number:08/387,749
Patent Claims:see list of patent claims

Details for Patent 5,814,460

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial Diatide, Inc. (Londonderry, NH) 2015-09-29 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

International Patent Family for US Patent 5,814,460

Country Patent Number Publication Date
World Intellectual Property Organization (WIPO) 9112331 Aug 22, 1991
World Intellectual Property Organization (WIPO) 9304079 Mar 04, 1993
World Intellectual Property Organization (WIPO) 9404558 Mar 03, 1994
United States of America 5366862 Nov 22, 1994
Japan H05506774 Oct 07, 1993
Japan H07502111 Mar 02, 1995
Israel 102897 Jan 31, 1993
>Country >Patent Number >Publication Date

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