Patent: 5,814,460

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Summary for Patent: 5,814,460

Title:	Method for generating and screening useful peptides
Abstract:	The invention allows the generation and screening of a large population of peptides for the presence of peptides which bind a particular macromolecule or macromolecular complex with high affinity, and further allows the favored net synthesis of analyzable quantities of such peptides, by using is the \"trap\" a macromolecule or macromolecular complex for which binding of the peptide is desired. The starting mixture is preferably spiked with a peptide having some affinity for the target macromolecule so that mutation of the spike or \"lead\" peptide is favored. The development of improved binding peptides through scrambling may be dynamically monitored by initially binding the target with an insolubilized ligand, and then looking for an increase in the concentration of the target in the soluble phase as a result of the displacement of the reference ligand by scrambled peptides.
Inventor(s):	Venton; Duane L. (Lombard, IL), Hopfinger; Anton J. (Lake Forest, IL), Lebreton; Guy (Oak Park, IL)
Assignee:	Diatide, Inc. (Londonderry, NH)
Application Number:	08/387,749
Patent Claims:	see list of patent claims

Details for Patent 5,814,460

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Number	Approval Date	Patent No.	Assignee	Patent Expiration	Status	Orphan	Source
Advance Biofactures	SANTYL	collagenase	VIAL	101995	001	1965-06-04	➤ Try a Free Trial	Diatide, Inc. (Londonderry, NH)	➤ Try a Free Trial	RX		search
Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Number	Approval Date	Patent No.	Assignee	Patent Expiration	Status	Orphan	Source

International Patent Family for US Patent 5,814,460

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Country	Patent Number	Publication Date
World Intellectual Property Organization (WIPO)	9112331	Aug 22, 1991
World Intellectual Property Organization (WIPO)	9304079	Mar 04, 1993
World Intellectual Property Organization (WIPO)	9404558	Mar 03, 1994
United States of America	5366862	Nov 22, 1994
Japan	H05506774	Oct 07, 1993
Japan	H07502111	Mar 02, 1995
Israel	102897	Jan 31, 1993
Country	Patent Number	Publication Date

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