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Patent: 5,814,460
Summary for Patent: 5,814,460
| Title: | Method for generating and screening useful peptides |
| Abstract: | The invention allows the generation and screening of a large population of peptides for the presence of peptides which bind a particular macromolecule or macromolecular complex with high affinity, and further allows the favored net synthesis of analyzable quantities of such peptides, by using is the \"trap\" a macromolecule or macromolecular complex for which binding of the peptide is desired. The starting mixture is preferably spiked with a peptide having some affinity for the target macromolecule so that mutation of the spike or \"lead\" peptide is favored. The development of improved binding peptides through scrambling may be dynamically monitored by initially binding the target with an insolubilized ligand, and then looking for an increase in the concentration of the target in the soluble phase as a result of the displacement of the reference ligand by scrambled peptides. |
| Inventor(s): | Venton; Duane L. (Lombard, IL), Hopfinger; Anton J. (Lake Forest, IL), Lebreton; Guy (Oak Park, IL) |
| Assignee: | Diatide, Inc. (Londonderry, NH) |
| Application Number: | 08/387,749 |
| Patent Claims: | see list of patent claims |
Details for Patent 5,814,460
| Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Number | Approval Date | Patent No. | Assignee | Estimated Patent Expiration | Status | Orphan | Source |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Smith And Nephew | SANTYL | collagenase | OINTMENT;TOPICAL | 101995 | 001 | 1965-06-04 | Start Trial | Diatide, Inc. (Londonderry, NH) | 2015-09-29 | RX | search | |
| >Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Number | >Approval Date | >Patent No. | >Assignee | >Estimated Patent Expiration | >Status | >Orphan | >Source |
International Patent Family for US Patent 5,814,460
| Country | Patent Number | Publication Date |
|---|---|---|
| World Intellectual Property Organization (WIPO) | 9112331 | Aug 22, 1991 |
| World Intellectual Property Organization (WIPO) | 9304079 | Mar 04, 1993 |
| World Intellectual Property Organization (WIPO) | 9404558 | Mar 03, 1994 |
| United States of America | 5366862 | Nov 22, 1994 |
| Japan | H05506774 | Oct 07, 1993 |
| Japan | H07502111 | Mar 02, 1995 |
| Israel | 102897 | Jan 31, 1993 |
| >Country | >Patent Number | >Publication Date |
