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Generated: July 17, 2019

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Patent: 5,811,252

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Summary for Patent: 5,811,252
Title: Modified proenzymes as substrates for proteolytic enzymes
Abstract:Detection or determination of a protease in a sample by incubating the sample with a substrate of the protease and observing proteolytic cleavage of said substrate. The substrate is a modified proenzyme containing a recognition site, e.g., an activation site, cleavable by said protease. Proteolytic cleavage of the modified proenzyme is detected by observing the resulting activity using a suitable substrate of the activated proenzyme. The protease may be e.g. an aspartic protease or a metalloprotease, and the modified proenzyme e.g. pro-urokinase having a mutant activation site which is cleavable by the protease to be determined.
Inventor(s): Verheijen; Johan Hendrikus (Rodenrijs, NL)
Assignee: Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO (NL)
Application Number:08/499,048
Patent Claims:see list of patent claims

Details for Patent 5,811,252

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source
Advance Biofactures SANTYL collagenase VIAL 101995 001 1965-06-04 ➤ Sign Up Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO (NL) ➤ Sign Up RX search
Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Patent Expiration Status Orphan Source

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