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Last Updated: September 29, 2020

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Patent: 5,811,248

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Summary for Patent: 5,811,248
Title: Atherosclerotic plaque specific antigens, antibodies thereto, and uses thereof
Abstract:An antigen comprising 5,7 cholestadien-3.beta.-ol (7-dehydrocholesterol) or a compound having a structure similar to 5,7 cholestadien-3.beta.-ol and a quaternary ammonium salt is provided. Also provided is a method of generating an antibody using the aforementioned antigen, as well as antibodies produced thereby and fragments of such antibodies. The invention also provides a rat myeloma cell line Z2D3 73/30 1D10 and a murine-human chimeric monoclonal antibody produced thereby. A CDR-grafted antibody comprising a CDR region amino acid sequence from hybridoma Z2D3 or hybridoma Z2D3/3E5 and framework and constant region amino acid sequences from a human immunoglobulin is further provided. Also provided are methods for imaging atherosclerotic plaque, ablating atherosclerotic plaque, detecting and quantitatively determining in a sample an antigen indicative of the presence of atherosclerotic plaque, reducing the amount of atherosclerotic plaque in a blood vessel, and treating atherosclerosis in a subject. The invention also provides peptides having amino acid sequences which are the same or substantially the same as those of the aforementioned murine-human chimeric monoclonal antibody, as well as isolated nucleic acid sequences encoding therefore.
Inventor(s): Ditlow; Charles C. (Fremont, CA), Chen; Francis W. (San Francisco, CA), Calenoff; Emanuel (Chicago, IL)
Assignee: Charter Ventures (Palo Alto, CA)
Application Number:08/480,434
Patent Claims:see list of patent claims

Details for Patent 5,811,248

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial Charter Ventures (Palo Alto, CA) 2015-09-22 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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Baxter
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Colorcon
Express Scripts

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