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Last Updated: September 27, 2020

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Patent: 5,798,113

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Summary for Patent: 5,798,113
Title: Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products
Abstract:A method of providing a biologically active molecule or metabolic or immunologic function to a patient, comprising implanting into the body of the patient at least one immunoisolatory vehicle comprising a core comprising a volume in excess of 1 .mu.l and at least about 10.sup.4 living cells dispersed in a biocompatible matrix formed of a hydrogel or extracellular matrix components, said cells being capable of secreting a biologically active product or of providing a metabolic or immunologic function to the patient; and an external jacket surrounding said core, said jacket being formed from a thermoplastic or hydrogel, said jacket being free of said cells projecting externally therefrom, said jacket being biocompatible and having a molecular weight cutoff permitting passage of molecules between the patient and the core through said jacket to provide said biologically active product of function.
Inventor(s): Dionne; Keith E. (Rehoboth, MA), Emerich; Dwaine F. (Providence, RI), Hoffman; Diane (Cambridge, MA), Sanberg; Paul R. (Spring Hill, FL), Christenson; Lisa (New Haven, CT), Hegre; Orion D. (Green Valley, AZ), Scharp; David W. (St. Louis, MO), Lacy; Paul E. (Webster Grove, MO), Aebischer; Patrick (Lutry, CH), Vasooncellos; Alfred V. (Cranston, RI), Lysaght; Michael J. (Greenwich, RI), Gentile; Frank T. (Warwich, RI)
Assignee: Brown University Research Foundation (N/A)
Application Number:08/449,524
Patent Claims:see list of patent claims

Details for Patent 5,798,113

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 001 2015-01-23   Start Trial Brown University Research Foundation (N/A) 2015-08-25 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23   Start Trial Brown University Research Foundation (N/A) 2015-08-25 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 003 2015-01-23   Start Trial Brown University Research Foundation (N/A) 2015-08-25 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 004 2015-01-23   Start Trial Brown University Research Foundation (N/A) 2015-08-25 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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