➤ Get the DrugPatentWatch Daily Briefing

Get Daily Updates on Generic Entry, Litigation, Biosimilars, and more …

Serving leading biopharmaceutical companies globally:

Colorcon
Dow
McKesson
Mallinckrodt
Moodys
McKinsey

Last Updated: September 21, 2020

DrugPatentWatch Database Preview

Patent: 5,786,347

➤ Get the DrugPatentWatch Daily Briefing
» See Plans and Pricing

« Back to Dashboard

Summary for Patent: 5,786,347
Title: Vitamin D amine and amide derivatives
Abstract:The invention relates to vitamin D amine and amide derivatives of general formula ##STR1## where R represents a hydrogen atom, an aliphatic, cycloaliphatic or araliphatic group, or an acyl group comprising an aliphatic, cycloaliphatic, arylaliphatic or aryl group linked to the nitrogen atom by way of a carbonyl group; R.sup.1 and R.sup.2 are each selected from lower alkyl and cycloalkyl groups or together with the carbon atom to which they are attached form a lower cycloalkyl group; R.sup.3 represents a methyl group having .alpha.- or .beta.-configuration; Y represents a lower alkylene, alkenylene or alkynylene group optionally substituted by a hydroxyl, etherified hydroxyl or esterified hydroxyl group; and A.dbd. represents a cyclohexylidene moiety characteristic of the A-ring of a 1 .alpha.-hydroxylated vitamin D or analogue thereof. Active compounds of the invention exhibit cell modulating activity and in certain cases may also have an effect on calcium metabolism. The compounds of the invention may be prepared by isomerizing a 5,6-trans isomer of formula (I) to a corresponding 5,6-cis isomer; by hydroxylating a 1-unsubstituted-5,6-trans analogue of a compound of formula (I) to prepare a 5,6-trans isomer of formula (I); by reacting a compound containing a precursor for the desired 17-position side chain in one or more stages and with one or more reactants serving to form the desired side chain; or by reacting a compound of formula (I) to modify the substitution pattern about the A.dbd. group.
Inventor(s): Hesse; Robert Henry (Winchester, MA), Setty; Sundara Katugam Srinivasaetty (Cambridge, MA), Ramgopal; Malathi (Andover, MA)
Assignee: Research Institute for Medicine and Chemistry, Inc. (Cambridge, MA)
Application Number:08/652,597
Patent Claims:see list of patent claims

Details for Patent 5,786,347

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 001 2015-01-23   Start Trial Research Institute for Medicine and Chemistry, Inc. (Cambridge, MA) 2013-12-13 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23   Start Trial Research Institute for Medicine and Chemistry, Inc. (Cambridge, MA) 2013-12-13 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 003 2015-01-23   Start Trial Research Institute for Medicine and Chemistry, Inc. (Cambridge, MA) 2013-12-13 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 004 2015-01-23   Start Trial Research Institute for Medicine and Chemistry, Inc. (Cambridge, MA) 2013-12-13 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

Make Better Decisions: Try a trial or see plans & pricing

Serving leading biopharmaceutical companies globally:

Merck
Colorcon
Mallinckrodt
Express Scripts
Dow
Johnson and Johnson

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.