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Last Updated: September 24, 2020

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Patent: 5,783,193

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Summary for Patent: 5,783,193
Title: Oral administration of therapeutic proteins for treatment of autoimmune disease, transplant rejection and infectious disease
Abstract:An orally administrable therapeutic protein is provided by combining the therapeutic protein with a stabilizing agent in an aqueous solution. The solution is coated onto nonpareils and microencapsulated with a water emulsifiable enteric coating composition. The microcapsules are orally administered. The coating protects the protein as it passes through the stomach. Upon reaching the small intestines, the basic pH of the intestinal juices will dissolve the coating, allowing the protein to be released and induce antigen specific immune response which has the specificity of the native molecule. The stabilizing agent protects the therapeutic protein from denaturation during the encapsulation process.
Inventor(s): Michael; J. Gabriel (Cincinnati, OH), Litwin; Allen (Cincinnati, OH)
Assignee: The University of Cincinnati (Cincinnati, OH)
Application Number:08/472,712
Patent Claims:see list of patent claims

Details for Patent 5,783,193

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial The University of Cincinnati (Cincinnati, OH) 2015-07-21 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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