DrugPatentWatch Database Preview
Patent: 5,780,279
Summary for Patent: 5,780,279
| Title: | Method of selection of proteolytic cleavage sites by directed evolution and phagemid display |
| Abstract: | A method for identifying and selecting novel substrates for enzymes is provided. The method comprises constructing a gene fusion comprising DNA encoding a polypeptide fused to DNA encoding a substrate peptide, which in turn is fused to DNA encoding at least a portion of a phage coat protein. The DNA encoding the substrate peptide is mutated at one or more codons thereby generating a family of mutants. The fusion protein is expressed on the surface of a phagemid particle and subjected to chemical or enzymatic modification of the substrate peptide. Those phagemid particles which have been modified are then separated from those that have not. |
| Inventor(s): | Matthews; David J. (San Francisco, CA), Wells; James A. (Burlingame, CA), Zoller; Mark J. (San Francisco, CA) |
| Assignee: | Genentech, Inc. (South San Francisco, CA) |
| Application Number: | 08/418,928 |
| Patent Claims: | see list of patent claims |
Details for Patent 5,780,279
| Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Number | Approval Date | Patent No. | Assignee | Estimated Patent Expiration | Status | Orphan | Source |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ethicon, Inc | THROMBIN HUMAN | thrombin human | POWDER, FOR SOLUTION | 125247 | 1 | 2009-09-19 | Start Trial | Genentech, Inc. (South San Francisco, CA) | 2039-02-26 | search | ||
| Nps Pharms Inc | NATPARA | parathyroid hormone | INJECTABLE;INJECTION | 125511 | 001 | 2015-01-23 | Start Trial | Genentech, Inc. (South San Francisco, CA) | 2039-02-26 | RX | Orphan | search |
| Nps Pharms Inc | NATPARA | parathyroid hormone | INJECTABLE;INJECTION | 125511 | 002 | 2015-01-23 | Start Trial | Genentech, Inc. (South San Francisco, CA) | 2039-02-26 | RX | Orphan | search |
| Nps Pharms Inc | NATPARA | parathyroid hormone | INJECTABLE;INJECTION | 125511 | 003 | 2015-01-23 | Start Trial | Genentech, Inc. (South San Francisco, CA) | 2039-02-26 | RX | Orphan | search |
| Nps Pharms Inc | NATPARA | parathyroid hormone | INJECTABLE;INJECTION | 125511 | 004 | 2015-01-23 | Start Trial | Genentech, Inc. (South San Francisco, CA) | 2039-02-26 | RX | Orphan | search |
| >Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Number | >Approval Date | >Patent No. | >Assignee | >Estimated Patent Expiration | >Status | >Orphan | >Source |
