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Last Updated: January 18, 2021

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Patent: 5,780,279

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Summary for Patent: 5,780,279
Title: Method of selection of proteolytic cleavage sites by directed evolution and phagemid display
Abstract:A method for identifying and selecting novel substrates for enzymes is provided. The method comprises constructing a gene fusion comprising DNA encoding a polypeptide fused to DNA encoding a substrate peptide, which in turn is fused to DNA encoding at least a portion of a phage coat protein. The DNA encoding the substrate peptide is mutated at one or more codons thereby generating a family of mutants. The fusion protein is expressed on the surface of a phagemid particle and subjected to chemical or enzymatic modification of the substrate peptide. Those phagemid particles which have been modified are then separated from those that have not.
Inventor(s): Matthews; David J. (San Francisco, CA), Wells; James A. (Burlingame, CA), Zoller; Mark J. (San Francisco, CA)
Assignee: Genentech, Inc. (South San Francisco, CA)
Application Number:08/418,928
Patent Claims:see list of patent claims

Details for Patent 5,780,279

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 004 2015-01-23   Start Trial Genentech, Inc. (South San Francisco, CA) 2039-02-26 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 003 2015-01-23   Start Trial Genentech, Inc. (South San Francisco, CA) 2039-02-26 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23   Start Trial Genentech, Inc. (South San Francisco, CA) 2039-02-26 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 001 2015-01-23   Start Trial Genentech, Inc. (South San Francisco, CA) 2039-02-26 RX Orphan search
Ethicon, Inc THROMBIN HUMAN thrombin human POWDER, FOR SOLUTION 125247 1 2009-09-19   Start Trial Genentech, Inc. (South San Francisco, CA) 2039-02-26 search
Microbix Biosystems KINLYTIC urokinase INJECTABLE;INJECTION 021846 003 1978-01-16   Start Trial Genentech, Inc. (South San Francisco, CA) 2039-02-26 DISCN search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

International Patent Family for US Patent 5,780,279

Country Patent Number Estimated Expiration
South Africa 967973   Start Trial
World Intellectual Property Organization (WIPO) 9004788   Start Trial
World Intellectual Property Organization (WIPO) 9209690   Start Trial
World Intellectual Property Organization (WIPO) 9711178   Start Trial
United States of America 2003153003   Start Trial
United States of America 2006115874   Start Trial
>Country >Patent Number >Estimated Expiration

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