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Last Updated: January 23, 2020

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Patent: 5,770,371

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Summary for Patent: 5,770,371
Title: Modification of cryptic splice sites in heterologous genes expressed in fungi
Abstract:The present invention relates to methods for obtaining a fungal host cell comprising a nucleic acid sequence encoding a heterologous polypeptide, wherein at least one cryptic splice site is modified in the nucleic acid sequence. The present invention also relates to a nucleic acid sequence(s) with a modified cryptic splice site(s) as well as nucleic acid constructs, vectors, and host cells comprising said nucleic acid sequence(s). The present invention further relates to methods for recombinant production of a polypeptide encoded by said nucleic acid sequence.
Inventor(s): Thompson; Sheryl (Davis, CA)
Assignee: Novo Nordisk Biotech, Inc. (Davis, CA)
Application Number:08/672,158
Patent Claims:see list of patent claims

Details for Patent 5,770,371

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Start Trial Novo Nordisk Biotech, Inc. (Davis, CA) 2039-02-26 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Start Trial Novo Nordisk Biotech, Inc. (Davis, CA) 2039-02-26 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Start Trial Novo Nordisk Biotech, Inc. (Davis, CA) 2039-02-26 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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