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Generated: September 17, 2019

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Patent: 5,756,733

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Summary for Patent: 5,756,733
Title: Vitamin D amide derivatives
Abstract:The invention relates to novel 1.alpha.-hydroxy vitamin D derivatives and their 20-epi analogues, comprising compounds of general formula (I) ##STR1## where R.sup.1 and R.sup.2, which may be the same or different, each represents a hydrogen atom or an aliphatic, cycloaliphatic, araliphatic or aryl group or together with the nitrogen atom to which they are attached form a heterocyclic group; R.sup.3 represents a methyl group having .alpha.- or .beta.-configuration; X represents a valence bond or a C.sub.1-2 alkylene group; Y represents --O--, --S--, --CH.sub.2 -- or --NR-- where R is a hydrogen atom or an organic group; Z represents a valence bond or a C.sub.1-3 alkylene group; and A.dbd. represents a cyclohexylidene moiety characteristic of the A-ring of a 1.alpha.-hydroxylated vitamin D or analogue thereof, with the proviso that when --X--Y--Z-- together represent an alkylene group containing up to 4 carbon atoms A.dbd. does not carry an exocyclic methylene group at the 10-position. Active compounds of the invention exhibit cell modulating activity while exhibiting a substantial lack of calcemic effect.
Inventor(s): Hesse; Robert Henry (Winchester, MA), Setty; Sundara Katugam Srinivasasetty (Cambridge, MA), Ramgopal; Malathi (Andover, MA)
Assignee: Research Institute for Medicine and Chemistry (Cambridge, MA)
Application Number:08/532,799
Patent Claims:see list of patent claims

Details for Patent 5,756,733

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 001 2015-01-23 ➤ Sign Up Research Institute for Medicine and Chemistry (Cambridge, MA) 2013-05-07 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23 ➤ Sign Up Research Institute for Medicine and Chemistry (Cambridge, MA) 2013-05-07 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 003 2015-01-23 ➤ Sign Up Research Institute for Medicine and Chemistry (Cambridge, MA) 2013-05-07 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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