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Generated: September 17, 2019

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Patent: 5,756,264

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Summary for Patent: 5,756,264
Title: Expression vector systems and method of use
Abstract:This invention relates to gene therapy by using vectors which encode stable MRNA and methods of using such vectors. In particular, this invention relates to vectors which establish controlled expression of recombinant genes within tissues at certain levels. The vector includes a 5\' flanking region which includes necessary sequences for expression of a nucleic acid cassette, a 3\' flanking region including a 3\' UTR and/or 3\' NCR which stabilizes mRNA expressed from the nucleic acid cassette, and a linker which connects the 5\' flanking region to a nucleic acid sequence. The linker has a position for inserting a nucleic acid cassette. The linker does not contain the coding sequence of a gene that the linker is naturally associated with. The 3\' flanking region is 3\' to the position for inserting the nucleic acid cassette. The expression vectors of the present invention can also be regulated by a regulatory system and/or constructed with a coating.
Inventor(s): Schwartz; Robert J. (Houston, TX), DeMayo; Franco J. (Houston, TX), O\'Malley; Bert W. (Houston, TX)
Assignee: Baylor College of Medicine (Houston, TX)
Application Number:08/209,846
Patent Claims:see list of patent claims

Details for Patent 5,756,264

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04 ➤ Sign Up Baylor College of Medicine (Houston, TX) 2015-05-26 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04 ➤ Sign Up Baylor College of Medicine (Houston, TX) 2015-05-26 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04 ➤ Sign Up Baylor College of Medicine (Houston, TX) 2015-05-26 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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