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Last Updated: December 2, 2021

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Patent: 5,756,264

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Summary for Patent: 5,756,264
Title: Expression vector systems and method of use
Abstract:This invention relates to gene therapy by using vectors which encode stable MRNA and methods of using such vectors. In particular, this invention relates to vectors which establish controlled expression of recombinant genes within tissues at certain levels. The vector includes a 5\' flanking region which includes necessary sequences for expression of a nucleic acid cassette, a 3\' flanking region including a 3\' UTR and/or 3\' NCR which stabilizes mRNA expressed from the nucleic acid cassette, and a linker which connects the 5\' flanking region to a nucleic acid sequence. The linker has a position for inserting a nucleic acid cassette. The linker does not contain the coding sequence of a gene that the linker is naturally associated with. The 3\' flanking region is 3\' to the position for inserting the nucleic acid cassette. The expression vectors of the present invention can also be regulated by a regulatory system and/or constructed with a coating.
Inventor(s): Schwartz; Robert J. (Houston, TX), DeMayo; Franco J. (Houston, TX), O\'Malley; Bert W. (Houston, TX)
Assignee: Baylor College of Medicine (Houston, TX)
Application Number:08/209,846
Patent Claims:see list of patent claims

Details for Patent 5,756,264

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 1986-06-04 ⤷  Free Forever Trial 2015-05-26
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 ⤷  Free Forever Trial 2015-05-26
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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Boehringer Ingelheim
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