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Last Updated: November 29, 2021

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Patent: 5,753,485

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Summary for Patent: 5,753,485
Title: Purified mixture of collagenase I, collagenase II and two other proteases
Abstract:A purified enzyme mixture useful for isolating cells or cell clusters from tissue is disclosed. The mixture includes at least two collagenase enzymes, at least two other proteases, and additional non-protease components. The mixture is purified by removing at least some of the non-protease components. The purified mixture may then be used to isolate cells or cell clusters from tissue. Also disclosed are the essential components of the purified enzyme mixture as well as preferred ranges and ratios of these essential components for isolating cells or cell clusters from tissue. Finally, a dissociation system is disclosed that can be used with the purified enzyme mixture to dissociate tissue and recover cells or cell clusters.
Inventor(s): Dwulet; Francis E. (Greenwood, IN), Ellis; Bernice B. (Greenfield, IN), Gill; John F. (Indianapolis, IN), Jacobsen; Linda B. (Indianapolis, IN), Smith; Marilyn E. (McCordsville, IN), Waters; David G. (Indianapolis, IN)
Assignee: Boehringer Mannheim Corporation (Indianapolis, IN)
Application Number:08/590,957
Patent Claims:see list of patent claims

Details for Patent 5,753,485

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Smith & Nephew, Inc. SANTYL collagenase Ointment 101995 1965-06-04 ⤷  Try it Free 2014-06-24
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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