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Last Updated: November 28, 2021

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Patent: 5,747,453

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Summary for Patent: 5,747,453
Title: Method for increasing the electrotransport flux of polypeptides
Abstract:Methods for modifying polypeptide agents to enhance their transdermal electrotransport flux are provided. The polypeptide is modified by reducing the potential of the polypeptide for forming .alpha.-helical or .beta.-sheet segments. In particular, amino acid residues known to stabilize .alpha.-helical and .beta.-sheet segments can be replaced with destabilizing residues and known helix breakers. Modified molecules and compositions including the molecules are also provided.
Inventor(s): Holladay; Leslie A. (Mountain View, CA), Oldenburg; Kevin R. (Fremont, CA)
Assignee: ALZA Corporation (Palo Alto, CA)
Application Number:08/468,275
Patent Claims:see list of patent claims

Details for Patent 5,747,453

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Nps Pharmaceuticals, Inc. NATPARA parathyroid hormone For Injection 125511 2015-01-23 ⤷  Free Forever Trial 2039-03-29
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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