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Last Updated: September 20, 2020

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Patent: 5,739,407

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Summary for Patent: 5,739,407
Title: Human .beta.-casein, process for producing it and use thereof
Abstract:The present invention relates to a DNA sequence encoding the human milk protein .beta.-casein or an analogue or variant thereof which has either the calcium binding activity of human .beta.-casein, or opioid activity, or angiotensin converting enzyme (ACE) inhibitory activity, or a combination of any two or three of these activities. The DNA sequence may optionally contain one or more intron sequences and permissive RNA splice signals. The DNA sequence is used in the production of recombinant human .beta.-casein, advantageously by means of production in transgenic non-human mammals such as bovine species. In one embodiment, the DNA sequence is inserted into a milk protein gene of a mammal such as a whey acidic protein (WAP) gene. The main use of the recombinant human .beta.-casein is as a constituent of infant formulae. It is contemplated that the recombinant human .beta.-casein provides a substantial improvement of the nutritional and biological value of the formulae in that a closer similarity to human milk is obtained.
Inventor(s): Bergstrom; Sven (Umea, SE), Hernell; Olle (Umea, SE), Lonnerdal; Bo (Davis, CA), Hjalmarsson; Karin (Umea, SE), Hanson; Lennart (Umea, SE), Tornell; Jan (Goteborg, SE), Stromqvigt; Mats (Umea, SE)
Assignee: Symbicom aktiebolag (Umea, SE)
Application Number:08/078,090
Patent Claims:see list of patent claims

Details for Patent 5,739,407

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Start Trial Symbicom aktiebolag (Umea, SE) 2015-04-14 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Start Trial Symbicom aktiebolag (Umea, SE) 2015-04-14 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Start Trial Symbicom aktiebolag (Umea, SE) 2015-04-14 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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