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Last Updated: October 6, 2022

Patent: 5,739,407

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Summary for Patent: 5,739,407
Title: Human .beta.-casein, process for producing it and use thereof
Abstract:The present invention relates to a DNA sequence encoding the human milk protein .beta.-casein or an analogue or variant thereof which has either the calcium binding activity of human .beta.-casein, or opioid activity, or angiotensin converting enzyme (ACE) inhibitory activity, or a combination of any two or three of these activities. The DNA sequence may optionally contain one or more intron sequences and permissive RNA splice signals. The DNA sequence is used in the production of recombinant human .beta.-casein, advantageously by means of production in transgenic non-human mammals such as bovine species. In one embodiment, the DNA sequence is inserted into a milk protein gene of a mammal such as a whey acidic protein (WAP) gene. The main use of the recombinant human .beta.-casein is as a constituent of infant formulae. It is contemplated that the recombinant human .beta.-casein provides a substantial improvement of the nutritional and biological value of the formulae in that a closer similarity to human milk is obtained.
Inventor(s): Bergstrom; Sven (Umea, SE), Hernell; Olle (Umea, SE), Lonnerdal; Bo (Davis, CA), Hjalmarsson; Karin (Umea, SE), Hanson; Lennart (Umea, SE), Tornell; Jan (Goteborg, SE), Stromqvigt; Mats (Umea, SE)
Assignee: Symbicom aktiebolag (Umea, SE)
Application Number:08/078,090
Patent Claims:see list of patent claims

Details for Patent 5,739,407

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 06/04/1986 See Plans and Pricing 2015-04-14
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 See Plans and Pricing 2015-04-14
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b Injection 103132 See Plans and Pricing 2015-04-14
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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