Patent: 5,739,033

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Summary for Patent: 5,739,033

Title:	Physiological cell separation and method of separating cells using same
Abstract:	An aqueous composition, initially present as a two-phase gradient, useful for separation of two cell types, such as islet cells from acinar cells, is disclosed, as well as a method of separating the cells. The composition is comprised of a water soluble, metabolically inert substance which maintains density, osmolarity and pH in the presence of cells, and a physiological cold storage solution comprising viscosity modifiers to increase the viscosity and osmotically active impermeant agents for suppressing cold-induced cellular edema, and also comprising a physiological solution capable of maintaining viable cells. These solutions are present in various combinations in a concentration sufficient to provide a first solution with a density greater than both cell types in their natural state, and less than the second cell type after incubation in said solution, and a second solution having a density less than that of both cell types. The system is allowed to stand or is centrifuged to separate the cells.
Inventor(s):	Soon-Shiong; Patrick (Los Angeles, CA)
Assignee:	Vivorx, Inc. (Santa Monica, CA)
Application Number:	08/486,404
Patent Claims:	see list of patent claims

Details for Patent 5,739,033

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965	See Plans and Pricing	2015-04-14
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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