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Patent: 5,739,033
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Summary for Patent: 5,739,033
Title: | Physiological cell separation and method of separating cells using same |
Abstract: | An aqueous composition, initially present as a two-phase gradient, useful for separation of two cell types, such as islet cells from acinar cells, is disclosed, as well as a method of separating the cells. The composition is comprised of a water soluble, metabolically inert substance which maintains density, osmolarity and pH in the presence of cells, and a physiological cold storage solution comprising viscosity modifiers to increase the viscosity and osmotically active impermeant agents for suppressing cold-induced cellular edema, and also comprising a physiological solution capable of maintaining viable cells. These solutions are present in various combinations in a concentration sufficient to provide a first solution with a density greater than both cell types in their natural state, and less than the second cell type after incubation in said solution, and a second solution having a density less than that of both cell types. The system is allowed to stand or is centrifuged to separate the cells. |
Inventor(s): | Soon-Shiong; Patrick (Los Angeles, CA) |
Assignee: | Vivorx, Inc. (Santa Monica, CA) |
Application Number: | 08/486,404 |
Patent Claims: | see list of patent claims |
Details for Patent 5,739,033
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Number | Approval Date | Patent No. | Assignee | Estimated Patent Expiration | Status | Orphan | Source |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Smith And Nephew | SANTYL | collagenase | OINTMENT;TOPICAL | 101995 | 001 | 1965-06-04 | Start Trial | Vivorx, Inc. (Santa Monica, CA) | 2015-04-14 | RX | search | |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Number | >Approval Date | >Patent No. | >Assignee | >Estimated Patent Expiration | >Status | >Orphan | >Source |
International Patent Family for US Patent 5,739,033
Country | Patent Number | Estimated Expiration |
---|---|---|
World Intellectual Property Organization (WIPO) | 9104318 | Start Trial |
Japan | H06503466 | Start Trial |
European Patent Office | 0578631 | Start Trial |
Germany | 69027686 | Start Trial |
Canada | 2066761 | Start Trial |
>Country | >Patent Number | >Estimated Expiration |