Patent: 5,739,033

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Summary for Patent: 5,739,033

Title:	Physiological cell separation and method of separating cells using same
Abstract:	An aqueous composition, initially present as a two-phase gradient, useful for separation of two cell types, such as islet cells from acinar cells, is disclosed, as well as a method of separating the cells. The composition is comprised of a water soluble, metabolically inert substance which maintains density, osmolarity and pH in the presence of cells, and a physiological cold storage solution comprising viscosity modifiers to increase the viscosity and osmotically active impermeant agents for suppressing cold-induced cellular edema, and also comprising a physiological solution capable of maintaining viable cells. These solutions are present in various combinations in a concentration sufficient to provide a first solution with a density greater than both cell types in their natural state, and less than the second cell type after incubation in said solution, and a second solution having a density less than that of both cell types. The system is allowed to stand or is centrifuged to separate the cells.
Inventor(s):	Soon-Shiong; Patrick (Los Angeles, CA)
Assignee:	Vivorx, Inc. (Santa Monica, CA)
Application Number:	08/486,404
Patent Claims:	see list of patent claims

Details for Patent 5,739,033

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Number	Approval Date	Patent No.	Assignee	Estimated Patent Expiration	Status	Orphan	Source
Advance Biofactures	SANTYL	collagenase	VIAL	101995	001	1965-06-04	➤ Sign Up	Vivorx, Inc. (Santa Monica, CA)	2015-04-14	RX		search
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Number	>Approval Date	>Patent No.	>Assignee	>Estimated Patent Expiration	>Status	>Orphan	>Source

International Patent Family for US Patent 5,739,033

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Country	Patent Number	Publication Date
Austria	140033	Jul 15, 1996
Australia	6517890	Apr 18, 1991
Canada	2066761	Mar 21, 1991
Canada	2066761	Nov 16, 1999
Germany	69027686	Aug 08, 1996
Germany	69027686	Jan 23, 1997
>Country	>Patent Number	>Publication Date

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