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Last Updated: September 26, 2022

Patent: 5,738,864


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Summary for Patent: 5,738,864
Title: Drug delivery agents incorporating mitomycin
Abstract:A conjugate of a carrier polymer and aziridine ring containing mitomycin (MMC) drug molecules is prepared by coupling the MMC molecules via their aziridine imino groups to spacer groups that terminate in protected amino groups, deprotecting said amino groups, recovering and purifying the spacer-MMC derivatives, and then coupling these derivatives via said deprotected amino groups to the carrier polymer. Alternatively, the MMC may first be treated with an activating agent, e.g. carbodiimidazole, to form an activated MMC derivative which is then coupled directly to spacer groups linked to the carrier polymer.
Inventor(s): Schacht; Etienne Honore (Staden, BE), Duncan; Ruth (London, GB), Ferruti; Paolo (Milan, IT)
Assignee: European Community (Luxemburg, DE)
Application Number:08/602,733
Patent Claims:see list of patent claims

Details for Patent 5,738,864

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Smith & Nephew, Inc. SANTYL collagenase Ointment 101995 06/04/1965 See Plans and Pricing 2013-08-18
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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