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Last Updated: September 24, 2020

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Patent: 5,738,864

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Summary for Patent: 5,738,864
Title: Drug delivery agents incorporating mitomycin
Abstract:A conjugate of a carrier polymer and aziridine ring containing mitomycin (MMC) drug molecules is prepared by coupling the MMC molecules via their aziridine imino groups to spacer groups that terminate in protected amino groups, deprotecting said amino groups, recovering and purifying the spacer-MMC derivatives, and then coupling these derivatives via said deprotected amino groups to the carrier polymer. Alternatively, the MMC may first be treated with an activating agent, e.g. carbodiimidazole, to form an activated MMC derivative which is then coupled directly to spacer groups linked to the carrier polymer.
Inventor(s): Schacht; Etienne Honore (Staden, BE), Duncan; Ruth (London, GB), Ferruti; Paolo (Milan, IT)
Assignee: European Community (Luxemburg, DE)
Application Number:08/602,733
Patent Claims:see list of patent claims

Details for Patent 5,738,864

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04   Start Trial European Community (Luxemburg, DE) 2013-08-18 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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