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Last Updated: September 19, 2020

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Patent: 5,733,540

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Summary for Patent: 5,733,540
Title: Protection from viral infection via colonization of mucosal membranes with genetically modified bacteria
Abstract:This invention relates to the use of genetically modified, non-pathogenic bacteria on the mucosal surfaces of a host to inhibit infection by specific viruses at mucosal surfaces. Specifically, non-pathogenic bacteria are modified to acquire the capacity to bind and functionally inactivate specific viruses. Further manipulations are devised to ensure the persistent colonization of said bacteria on the desired mucosal surface of a host. The capacity to bind a pathogen by said bacteria may be accomplished through the expression on the bacterial surface of a molecule, either a polypeptide or carbohydrate moiety, which binds specifically to a molecule on the target virus. Such a capacity may be conferred upon said bacteria via genetic manipulations. Genetic manipulations of said bacteria may be carried out in vitro and the genetically-engineered bacteria applied onto the desired mucosal surface of a host, or genetic material may be directly introduced into bacteria which are already resident on the desired mucosal surface of a host through a vector.
Inventor(s): Lee; Peter Poon-Hang (Palo Alto, CA)
Assignee:
Application Number:08/401,070
Patent Claims:see list of patent claims

Details for Patent 5,733,540

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Bausch And Lomb VITRASE hyaluronidase INJECTABLE;INJECTION 021640 001 2004-12-21   Start Trial 2039-03-29 RX search
Bausch And Lomb VITRASE hyaluronidase INJECTABLE;INJECTION 021640 002 2004-12-21   Start Trial 2039-03-29 RX search
Amphastar Pharm AMPHADASE hyaluronidase INJECTABLE;INJECTION 021665 001 2005-11-03   Start Trial 2039-03-29 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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