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Last Updated: August 5, 2021

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Patent: 5,721,139

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Summary for Patent: 5,721,139
Title: Isolating and culturing schwann cells
Abstract:A method for enhancing the survival and/or proliferation of Schwann cells (especially human Schwann cells) in cell culture is disclosed which involves culturing the cells in serum free culture medium comprising gas6 and other mitogenic agents, such as heregulin and forskolin. The culturing step is generally preceded by a pre-incubation period wherein nerve tissue comprising the Schwann cells is cultured under appropriate conditions and for a period of time such that demyelination occurs. The isolated Schwann cells can be used as cellular prostheses to treat patients with nervous system injuries. The invention also provides a cell culture medium for culturing Schwann cells.
Inventor(s): Mather; Jennie P. (Millbrae, CA), Li; Ronghao (Millbrae, CA), Chen; Jian (Burlingame, CA)
Assignee: Genentech, Inc. (South San Francisco, CA)
Application Number:08/435,436
Patent Claims:see list of patent claims

Details for Patent 5,721,139

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04 ⤷  Try it Free Genentech, Inc. (South San Francisco, CA) 2039-02-26 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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Serving leading biopharmaceutical companies globally:

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