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Last Updated: December 1, 2021

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Patent: 5,720,936

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Summary for Patent: 5,720,936
Title: Transgenic mouse assay for compounds affecting amyloid protein processing
Abstract:The construction of transgenic animal models for testing potential treatments for Alzheimer\'s disease are described. The models are characterized by a greater similarity to the conditions existing in naturally occurring Alzheimer\'s disease, based on expression of all three forms of the .beta.-amyloid precursor protein (APP), APP.sub.695, APP.sub.751, and APP.sub.770), as well as various point mutations based on naturally occurring mutations, such as the London and Indiana familial Alzheimer\'s disease (FAD) mutations at amino acid 717, and predicted mutations in the APP gene. The APP gene constructs are prepared using the naturally occurring promoter, as well as inducible promoters such as the mouse metallothionine promoter, which can be regulated by addition of heavy metals such as zinc to the animal\'s water or diet, and promoters such as the rat neuron specific enolase promoter, human .beta. actin gene promoter, human platelet derived growth factor B (PDGF-B) chain gene promoter, rat sodium channel gene promoter, mouse myelin basic protein gene promoter, human copper-zinc superoxide dismutase gene promoter, and mammalian POU-domain regulatory gene promoter. The constructs are introduced into animal embryos using standard techniques such as microinjection. Animal cells can be isolated from the transgenic animals or prepared using the same constructs with standard techniques such as lipofection or electroporation. The transgenic animals, or animal cells, are used to screen for compounds altering the pathological course of Alzheimer\'s Disease as measured by their effect on the amount and histopathology of APP and .beta.-amyloid peptide in the animals, as well as by behavioral alterations.
Inventor(s): Wadsworth; Samuel (Shrewsbury, MA), Snyder; Benjamin (Worcester, MA), Wei; Cha-Mer (Framingham, MA), Leibowitz; Paul J. (Brookline, MA)
Assignee: Athena Neurosciences, Inc. (South San Francisco, CA)
Application Number:08/282,227
Patent Claims:see list of patent claims

Details for Patent 5,720,936

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 1986-06-04 ⤷  Try it Free 2015-02-24
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 ⤷  Try it Free 2015-02-24
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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