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Last Updated: July 30, 2021

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Patent: 5,718,897

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Summary for Patent: 5,718,897
Title: Enhancing keratinocyte migration and proliferation
Abstract:A method of enhancing the migration and proliferation of keratinocytes in wound healing or in the growth of artificial skin grown in vitro. The wound is contacted with (a) an effective amount of purified Clostridiopeptidase A collagenase that is substantially free from other proteinases and (b) an amount of a growth factor that increases the effects of said collagenase. The artificial skin is grown upon biomatrices previously synthesized by living cells and digested with Clostridiopeptidase A collagenase while in the presence of (a) an effective concentration of purified Clostridiopeptidase A collagenase substantially free from other proteinases and (b) a growth factor in a concentration effective to increase the effectiveness of said collagenase.
Inventor(s): Herman; Ira M. (Newton, MA)
Assignee: Trustees of Tufts College (Medford, MA)
Application Number:08/777,267
Patent Claims:see list of patent claims

Details for Patent 5,718,897

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04 ⤷  Free Forever Trial Trustees of Tufts College (Medford, MA) 2015-06-07 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

International Patent Family for US Patent 5,718,897

Country Patent Number Estimated Expiration
United States of America 5851522 ⤷  Free Forever Trial
Japan H08333278 ⤷  Free Forever Trial
Japan H10212244 ⤷  Free Forever Trial
European Patent Office 0751217 ⤷  Free Forever Trial
European Patent Office 0852144 ⤷  Free Forever Trial
Germany 69732616 ⤷  Free Forever Trial
Canada 2178396 ⤷  Free Forever Trial
>Country >Patent Number >Estimated Expiration

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