Protein active in humoral hypercalcemia of malignancy-PTHrP
A sub-unit or fragment of parathyroid hormone related protein having the following characteristics: (a) an N-terminal amino acid sequence A V S E H Q L L H D K G K S I Q D L R R R F F L H H L I A E I H T A E I R A T S E V S P N; (b) a molecular weight between 15 to 25 kilodaltons, as determined by sodium dodecyl polyacrylamide gel electrophoresis under reducing and non-reducing conditions; and (c) a specific biological activity of at least about 6 mg equivalents of a peptide composed of amino acids 1-34 a parathyroid hormone related protein per mg protein as measured in an adenylate cyclase response assay.
Martin; Thomas J. (Kew, AU), Moseley; Jane M. (North Balwyn, AU), Kemp; Bruce E. (Kew, AU), Wettenhall; Richard E. H. (Camberwell, AU)
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