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Last Updated: July 30, 2021

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Patent: 5,674,722

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Summary for Patent: 5,674,722
Title: Genetic modification of endothelial cells
Abstract:Endothelial cells transduced with genetic material encoding a polypeptide or protein of interest and, optionally, a selectable marker, as well as methods for making and using the transduced endothelial cells are disclosed. Such endothelial cells are useful in improving the performance of vascular grafts and in delivering the encoded polypeptide or protein, such as an enzyme, a hormone, a receptor or a drug, to an individual.
Inventor(s): Mulligan; Richard C. (Lincoln, MA), Cohen; Lawrence K. (Oakland, CA), Rafield; Lori F. (San Fransisco, CA), Birinyi; Louis K. (Boston, MA), Callow; Allan D. (St. Louis, MO), Wilson; James M. (Ann Arbor, MI)
Assignee: Somatix Therapy Corporation (Alameda, CA) Whitehead Institute For Biomedical Research (Cambridge, MA) Brigham & Womens Hospital (Boston, MA) Howard Hughes Medical Institute (Bethesda, MD) New England Medical Center Hospitals (Boston, MA)
Application Number:08/249,092
Patent Claims:see list of patent claims

Details for Patent 5,674,722

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 004 2015-01-23 ⤷  Free Forever Trial Somatix Therapy Corporation (Alameda, CA) Whitehead Institute For Biomedical Research (Cambridge, MA) Brigham & Womens Hospital (Boston, MA) Howard Hughes Medical Institute (Bethesda, MD) New England Medical Center Hospitals (Boston, 2014-10-07 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 003 2015-01-23 ⤷  Free Forever Trial Somatix Therapy Corporation (Alameda, CA) Whitehead Institute For Biomedical Research (Cambridge, MA) Brigham & Womens Hospital (Boston, MA) Howard Hughes Medical Institute (Bethesda, MD) New England Medical Center Hospitals (Boston, 2014-10-07 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23 ⤷  Free Forever Trial Somatix Therapy Corporation (Alameda, CA) Whitehead Institute For Biomedical Research (Cambridge, MA) Brigham & Womens Hospital (Boston, MA) Howard Hughes Medical Institute (Bethesda, MD) New England Medical Center Hospitals (Boston, 2014-10-07 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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