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Last Updated: November 27, 2021

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Patent: 5,670,369

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Summary for Patent: 5,670,369
Title: Method for the production of soluble collagen
Abstract:The invention includes an improved method for producing an aqueous solution of soluble collagen. The method comprises the steps of: (A) providing an aqueous ground slurry of insoluble collagen containing insoluble collagen at a first concentration and at a pH effective to obtain activity for a proteolytic enzyme added in step (B); (B) adding a proteolytic enzyme to said slurry; (C) reacting said slurry and enzyme at a temperature, T.sub.1, and for a time t.sub.1 effective for forming a slurry containing at least some soluble collagen; (D) diluting at least a portion of the slurry formed in step (C) with water to form a diluted slurry containing insoluble collagen at a second concentration; and (E) reacting said diluted slurry obtained in step (D) at a temperature, T.sub.2 and for a time t.sub.2, effective to produce a solution containing an increased amount of soluble collagen. The improved process of the present invention permits the preparation of soluble collagen utilizing reduced amounts of enzyme and water, and requires less time at low concentration for completion of the reaction.
Inventor(s): Fink; David J. (Shaker Hts., OH), Virnelson; Kevin M. (Mayfield Hts., OH)
Assignee: Ranpak Corporation (Concord, OH)
Application Number:08/670,338
Patent Claims:see list of patent claims

Details for Patent 5,670,369

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Discure Medical, Llc CHYMODIACTIN chymopapain For Injection 018663 1982-11-10 ⤷  Try it Free 2039-03-29
Discure Medical, Llc CHYMODIACTIN chymopapain For Injection 018663 1984-08-21 ⤷  Try it Free 2039-03-29
Smith & Nephew, Inc. SANTYL collagenase Ointment 101995 1965-06-04 ⤷  Try it Free 2039-03-29
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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