Transgenic mice expressing a mutated human collagen gene
The invention is transgenic mice substantially all of whose cells contain a mutated human collagen gene. Methods for testing therapies for the treatment of osteogenesis imperfecta, osteoporosis, and chondrodysplasia are provided.
Prockop; Darwin J. (Philadelphia, PA), Ala-Kokko; Leena (Philadelphia, PA), Khillan; Jaspal S. (Philadelphia, PA), Vandenberg; Philipp (Philadelphia, PA), Kontusaari; Sirpa (Oulu, FI), Helminen; Heikki (Philadelphia, PA), Olsen; Anne (Moraga, CA), Sokolov; Boris (Philadelphia, PA)
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