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Last Updated: November 27, 2021

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Patent: 5,662,604

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Summary for Patent: 5,662,604
Title: Monitoring method of renal lesions without clinical signs
Abstract:A screening method for detecting renal lesions in diabetic patients not yet exhibiting symptoms of nephropathy, comprising administering a predetermined dose of parathyroid hormone, analogue thereof or derivative thereof to the patients with an albumin excretion rate (AER) of microalbumin being below 15 .mu.g/min., measuring urinary excreted N-acetyl-.beta.-D-glucosaminidase (NAG) and urinary creatinine in urinary samples taken 60.+-.10 minutes before and after administration of PTH, and monitoring the increased ratio of urinary excreted NAG (U/g Cr) in post-administration of PTH to the urinary excreted NAG (U/g Cr) in pre-administration of PTH for a value less than 2.3. The screening method provides the possibility of detecting renal lesions without clinical signs of diabetic nephropathy, using a preparation essentially consisting of active ingredient of PTH.
Inventor(s): Ogata; Etsuro (Tokyo, JP), Kurokawa; Kiyoshi (Tokyo, JP), Uchida; Shunya (Tokyo, JP), Kishida; Akiko (Kanagawa, JP)
Assignee: Asahi Kasei Kogyo Kabushiki Kaisha (Osaka, JP)
Application Number:08/495,635
Patent Claims:see list of patent claims

Details for Patent 5,662,604

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Nps Pharmaceuticals, Inc. NATPARA parathyroid hormone For Injection 125511 2015-01-23 ⤷  Try it Free 2039-03-29
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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