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Last Updated: September 30, 2020

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Patent: 5,656,455

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Summary for Patent: 5,656,455
Title: Method and compositions for making ACSF and ACSF antagonists
Abstract:The complete amino acid and nucleotide sequence for adenylate cyclase stimulating factor is provided, thereby facilitating the synthesis of ACSF in recombinant cell culture. ACSF amino acid sequence variants and ACSF antibodies are provided which are useful in the treatment of humoral hypercalcemia of malignancy or in immunoassays for ACSF. In particular, antibodies capable of binding only the C-terminal domains of ACSF are useful in immunoassays for ACSF which avoid interference by parathyroid hormone. Also provided are novel polypeptides selected from the group of the ACSF basic peptide, the ACSF C-terminal peptide, or the ACSF domain containing both of the basic and C-terminal peptides.
Inventor(s): Wood; William I. (San Mateo, CA), Martin; Thomas John (Victoria, AU), Suva; Larry John (Victoria, AU)
Assignee: University of Melbourne (Victoria, AU)
Application Number:08/330,131
Patent Claims:see list of patent claims

Details for Patent 5,656,455

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 001 2015-01-23   Start Trial University of Melbourne (Victoria, AU) 2014-08-12 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23   Start Trial University of Melbourne (Victoria, AU) 2014-08-12 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 003 2015-01-23   Start Trial University of Melbourne (Victoria, AU) 2014-08-12 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 004 2015-01-23   Start Trial University of Melbourne (Victoria, AU) 2014-08-12 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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