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Last Updated: March 30, 2023

Patent: 5,643,746


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Summary for Patent: 5,643,746
Title: Human epidermal gene promoter
Abstract:The present invention relates to promoter elements from human type I transglutaminase (TGase I) genes for controlled gene expression of both human TGase I and heterologous proteins. These promoter elements permit tissue-specific expression of genes, e.g. for use in human gene therapy and for testing pharmaceutical agents with artificial skin. Additionally, the subject promoter elements can provide differential regulation under physiological conditions or in the presence of exogenously added factors including calcium and retinoic acid.
Inventor(s): Polakowska; Renata Regina (Pittsford, NY), Goldsmith; Lowell Alan (Pittsford, NY)
Assignee: Research Corporation Technologies, Inc. (Tucson, AZ)
Application Number:08/216,219
Patent Claims:see list of patent claims

Details for Patent 5,643,746

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Nps Pharmaceuticals, Inc. NATPARA parathyroid hormone For Injection 125511 01/23/2015 ⤷  Sign Up 2014-07-01
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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