The present invention relates to promoter elements from human type I transglutaminase (TGase I) genes for controlled gene expression of both human TGase I and heterologous proteins. These promoter elements permit tissue-specific expression of genes, e.g. for use in human gene therapy and for testing pharmaceutical agents with artificial skin. Additionally, the subject promoter elements can provide differential regulation under physiological conditions or in the presence of exogenously added factors including calcium and retinoic acid.
Polakowska; Renata Regina (Pittsford, NY), Goldsmith; Lowell Alan (Pittsford, NY)
Research Corporation Technologies, Inc. (Tucson, AZ)
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