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Last Updated: August 11, 2020

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Patent: 5,631,322

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Summary for Patent: 5,631,322
Title: Polymers of N-acryloylmorpholine activated at one end and conjugates with bioactive materials and surfaces
Abstract:Polymers of the monomer N-acryloylmorpholine having a single reactive moiety at one end of the polymer chain have the following structure: ##STR1## wherein --Z--X--Y is a polymer capping moiety, such as mercaptan, X represents a saturated residue of a linear or branched aliphatic series of the general structure --C.sub.r H.sub.2r -- in which r is an integer from 1 to about 12, Y is a reactive moiety and typically will be one of the reactive moieties commonly known in PEG chemistry, such as an --OH, --COOH, or --NH.sub.2 group, Z is a moiety that readily reacts to cap a polymer free radical, and n is an integer from about 6 to 280, which yields a number average molecular weight (\"M.sub.n \") of from about 1,000 to 40,000. The monofunctional polymer is a suitable alternative to monofunctional PEG for modification of substances having biological and biotechnical applications.
Inventor(s): Veronese; Francesco M. (Padua, IT), Schiavon; Oddone (Padua, IT), Caliceti; Paolo (Padua, IT), Sartore; Luciana (Marano Vic., IT), Ranucci; Elisabetta (Brescia, IT), Ferruti; Paolo (Milan, IT)
Assignee: Consiglio Nazionale delle Ricerche (IT)
Application Number:08/475,177
Patent Claims:see list of patent claims

Details for Patent 5,631,322

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10   Start Trial Consiglio Nazionale delle Ricerche (IT) 2014-05-20 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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