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Last Updated: June 1, 2020

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Patent: 5,631,153

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Summary for Patent: 5,631,153
Title: Cells and non-human organisms containing predetermined genomic modifications and positive-negative selection methods and vectors for making same
Abstract:Positive-negative selector (PNS) vectors are provided for modifying a target DNA sequence contained in the genome of a target cell capable of homologous recombination. The vector comprises a first DNA sequence which contains at least one sequence portion which is substantially homologous to a portion of a first region of a target DNA sequence. The vector also includes a second DNA sequence containing at least one sequence portion which is substantially homologous to another portion of a second region of a target DNA sequence. A third DNA sequence is positioned between the first and second DNA sequences and encodes a positive selection marker which when expressed is functional in the target cell in which the vector is used. A fourth DNA sequence encoding a negative selection marker, also functional in the target cell, is positioned 5\' to the first or 3\' to the second DNA sequence and is substantially incapable of homologous recombination with the target DNA sequence. The invention also includes transformed cells containing at least one predetermined modification of a target DNA sequence contained in the genome of the cell. In addition, the invention includes organisms such as non-human transgenic animals and plants which contain cells having predetermined modifications of a target DNA sequence in the genome of the organism.
Inventor(s): Capecchi; Mario R. (Salt Lake City, UT), Thomas; Kirk R. (Salt Lake City, UT)
Assignee: University of Utah (Salt Lake City, UT)
Application Number:08/463,813
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 5,631,153
Patent Claims:see list of patent claims

Details for Patent 5,631,153

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Start Trial University of Utah (Salt Lake City, UT) 2014-05-20 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Start Trial University of Utah (Salt Lake City, UT) 2014-05-20 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 003 1986-06-04   Start Trial University of Utah (Salt Lake City, UT) 2014-05-20 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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