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Last Updated: September 24, 2022

Patent: 5,629,343

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Summary for Patent: 5,629,343
Title: N-(mercaptoacyl) peptidyl derivatives as antidegenerative agents
Abstract:Novel N-(mercaptoacyl)peptidyl compounds are useful as inhibitors of matrix metalloendoproteinases which degrade major components of articular cartilage and basement membranes causing degenerative diseases such as arthritis, periodontal disease, corneal ulceration, are described. For example, N-(2-thiomethyl-4-phenyl-butanoyl)-L-leucinamide was prepared and its inhibitory activity against stromelysin was tested in vitro.
Inventor(s): Hagmann; William (Westfield, NJ), Kopka; Ihor (Millburn, NJ)
Assignee: Merck & Co., Inc. (Rahway, NJ)
Application Number:08/392,730
Patent Claims:see list of patent claims

Details for Patent 5,629,343

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Smith & Nephew, Inc. SANTYL collagenase Ointment 101995 06/04/1965 See Plans and Pricing 2039-02-26
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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