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Last Updated: July 27, 2021

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Patent: 5,629,343

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Summary for Patent: 5,629,343
Title: N-(mercaptoacyl) peptidyl derivatives as antidegenerative agents
Abstract:Novel N-(mercaptoacyl)peptidyl compounds are useful as inhibitors of matrix metalloendoproteinases which degrade major components of articular cartilage and basement membranes causing degenerative diseases such as arthritis, periodontal disease, corneal ulceration, are described. For example, N-(2-thiomethyl-4-phenyl-butanoyl)-L-leucinamide was prepared and its inhibitory activity against stromelysin was tested in vitro.
Inventor(s): Hagmann; William (Westfield, NJ), Kopka; Ihor (Millburn, NJ)
Assignee: Merck & Co., Inc. (Rahway, NJ)
Application Number:08/392,730
Patent Claims:see list of patent claims

Details for Patent 5,629,343

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Smith And Nephew SANTYL collagenase OINTMENT;TOPICAL 101995 001 1965-06-04 ⤷  Try it Free Merck & Co., Inc. (Rahway, NJ) 2039-02-26 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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Serving leading biopharmaceutical companies globally:

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Boehringer Ingelheim

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