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Last Updated: July 28, 2021

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Patent: 5,618,710

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Summary for Patent: 5,618,710
Title: Crosslinked enzyme crystals
Abstract:A protein such as an enzyme of antibody is immobilized by crosslinking crystals of the protein with a multifunctional crosslinking agent. The crosslinked protein crystals may be lyophilized for storage. A preferred protein is an enzyme such as thermolysin, elastase, asparaginase, lysozyme, lipase or urease. Crosslinked enzyme crystals preferably retain at least 91% activity after incubation for three hours in the presence of a concentration of Pronase.TM. that causes the soluble uncrosslinked form of the enzyme to lose at least 94% of its initial activity under the same conditions. A preferred enzyme:Pronase.TM. ratio is 1:40. Enzyme crystals that are crosslinked may be microcrystals having a cross-section of 10.sup.-1 mm or less. Crosslinked enzyme or antibody crystals may be used in an assay, diagnostic kit or biosensor for detecting an analyte, in an extracorporeal device for altering a component of a fluid, in producing a product such as using crosslinked thermolysin crystals to produce aspartame, in separating a substance from a mixture, and in therapy.
Inventor(s): Navia; Manuel A. (Lexington, MA), St. Clair; Nancy L. (Charlestown, MA)
Assignee: Vertex Pharmaceuticals, Inc. (Cambridge, MA)
Application Number:08/017,510
Patent Claims:see list of patent claims

Details for Patent 5,618,710

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10 ⤷  Free Forever Trial Vertex Pharmaceuticals, Inc. (Cambridge, MA) 2014-04-08 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

International Patent Family for US Patent 5,618,710

Country Patent Number Estimated Expiration
World Intellectual Property Organization (WIPO) 9202617 ⤷  Free Forever Trial
United States of America 5801022 ⤷  Free Forever Trial
United States of America 5849296 ⤷  Free Forever Trial
United States of America 5976529 ⤷  Free Forever Trial
United States of America 6004768 ⤷  Free Forever Trial
United States of America 6011001 ⤷  Free Forever Trial
>Country >Patent Number >Estimated Expiration

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Serving leading biopharmaceutical companies globally:

Harvard Business School
Johnson and Johnson
Boehringer Ingelheim

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